American scientists and researchers ( Scripps Research Institute , Mayo Private Clinic, etc.) have discovered a new class of drugs that greatly slow down the aging process, reduce the effects of related diseases, improve the cardiovascular system and prolong life. The work was published in the journal Aging Cell. Scientists tested two drugs on animals. One of them is the directional antineoplastic agent dasatinib (trademark Sprycel). The second is quercetin , a substance that helps with swelling, spasms, inflammation, and is found in many fruits, vegetables, leaves and cereals.
As a result of experiments, it turned out that these drugs kill aging cells – those cells of the body that have stopped dividing and only accumulate with age, contributing to the aging of the body. Scientists have named the new class of drugs ” senolytics “. Researchers regard the finding as the first big step towards developing drugs that can prolong life and help fight age-related diseases. In combination, these two drugs have beneficial effects on mice and on human tissue cells. Dasatinib worked well with the cells that make up senescent human fat cells, and quercetin worked well with human vascular cells and murine stem cells from the bone marrow.
After the combination of drugs was injected into the old mice just once, they felt better for five days, and began to show much better results in various tests of physical endurance. Also, these drugs markedly improved the condition of mice weakened by chemotherapy drugs. The effect of just one injection of drugs in some cases persisted for as long as seven months. Periodic application of drugs to mice subject to accelerated aging increased their lifespan, delayed the onset of age-related symptoms, manifestations of spinal degeneration and osteoporosis. Medicines have a long way to go for side effects before they can be used in humans.